MiRNA-148b (miR-148b) had been reported to be downregulated, and it acts as a tumor suppressor in human lung cancer,6 glioma,7 pancreatic cancer8 and hepatocellular carcinoma.9 However, miR-148b is found to be upregulated in human ovarian carcinoma.10 In normal Schwann cells, the upregulation of miR-148b promoted cell migration.11 These studies suggest that miR-148b may play different roles in different situations.
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MiR-148b, as a member of the miR-148/152 family, plays important roles in development and diseases.22 MiR-148b had been reported to be downregulated in some human cancers.7,8,23 Dysregulated miR-148b in pancreatic cancer was correlated with increased tumor size, advanced clinical stage, distant metastasis and poor prognosis. Ectopic miR-148b expression inhibited the growth and metastasis of pancreatic cancer cells by targeting AMPKα1.8 In hepatocellular carcinoma, miR-148b negatively regulated WNT1/β-catenin pathway by targeting WNT.19 Moreover, miR-148b was critical in the maintenance of properties of cancer stem cells by targeting Neuropilin-1 in hepatocellular carcinoma, suggesting that the restoration of miR-148b may be a new therapeutic strategy by targeting cancer stem cells.24 miR-148b inhibits malignant behaviors of glioma cells through targeting HOTAIR.7 These studies, overall, revealed that miR-148b may play important roles in NPC. However, the functions of miR-148b in NPC are still largely unknown. 2ff7e9595c
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